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Transplacental pharmacokinetics of glyburide, rhodamine 123 and BODIPY FL prazosin; effect of drug efflux transporters and lipid solubility
Journal of Pharmacology and Experimental Therapeutics, 10/08/09

Cygalova LH et al. – The authors demonstrate the ability of placental ABC transporters to hinder maternal–to–fetal and accelerate fetal–to–maternal transport in a concentration–dependent manner. However, by means of pharmacokinetic modeling the authors describe the inverse correlation between lipid solubility of a molecule and its active transport by placental ABC efflux transporters.

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Opiate-induced hypernociception and chemokine receptors
Neuropharmacology, 11/10/09

Ketorolac But Not Morphine Exerts Inflammatory and Metabolic Effects in Synovial Membrane After Knee Arthroscopy: A Double-Blind Randomized Prospective Study Using the Microdialysis Technique
Regional Anesthesia and Pain Medicine, 11/04/09

Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1
Current Drug Targets, 11/03/09

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U-500 Regular Insulin: Clinical Experience and Pharmacokinetics in Obese, Severely Insulin Resistant Type 2 Diabetic Patients
Diabetes Care, 11/16/09

The role of ceramide in major depressive disorder
European Archives of Psychiatry and Clinical Neuroscience, 11/12/09

Randomized Trial and Pharmacokinetic Study of Pegfilgrastim versus Filgrastim after Dose-Intensive Chemotherapy in Young Adults and Children with Sarcomas
Clinical Cancer Research, 11/20/09

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