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Coccaro EF et al. – Physiologic responses to 5–HT stimulation are reduced as a function of aggression in human subjects. The same is true for personality disordered subjects with a history of suicidal, but not self–injurious, behavior and for subjects with a diagnosis of IED by research criteria. These data have particular relevance to the notion of impulsive aggression and the biological validity of IED.

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