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See Latest ArticlesCitric acid as a pH-modifying additive in an extended release pellet formulation containing a weakly basic drug
Drug Development and Industrial Pharmacy, 10/12/09
Ploen J et al. – The presented extended release pellet formulation is able to maintain a low pH within the pellet core and thus a sufficiently high drug solubility. By maintaining a low pH inside the pellets, a controlled drug release can be achieved.
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