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See Latest ArticlesComparison of the Anti-nociceptive and Anti-Rewarding Profiles of Novel Bifunctional Nociceptin/Orphanin FQ Receptor (NOPr)-Mu Opioid Receptor (MOPr) Ligands: Implications for Therapeutic Applications
Journal of Pharmacology and Experimental Therapeutics, 10/07/09
Toll LR et al. – These results suggest that NOPr full agonist activity is required to modulate opioid–induced reward whereas a bifunctional NOPr/MOPr partial agonist profile may be suitable as a non–addicting analgesic. The opioid–modulating effects of the NOPr ligands may be effectively utilized to produce better medications for treatment of drug abuse and pain.
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Today in Basic Science...keeping you current
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