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The effect of rifampin and nelfinavir on the metabolism of methadone and buprenorphine in primary cultures of human hepatocytes
Drug Metabolism and Disposition, 10/05/09
Moody DE et al. – The studies support the hypothesis that methadone metabolism and its potential for drug interactions can be predicted with cultured human hepatocytes, but for buprenorphine, combined effects of hepatic and small intestinal metabolism are likely involved.
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