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See Latest ArticlesPrediction of Human Drug and Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator
Drug Metabolism and Disposition, 10/06/09
Xu L et al. – The results suggest that DDI predictions from CYP3A4 TDI kinetics in hepatocytes could provide an alternative approach to balance HLM–based predictions that can sometimes substantially over–estimate DDIs and possibly lead to erroneous conclusions about clinical risks.
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A Conserved Motif in the Membrane Proximal C-Terminal Tail of Human Muscarinic M1 Acetylcholine Receptors Affects Plasma Membrane Expression
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Today in Drug Interactions...keeping you current
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