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See Latest ArticlesVacuolar ATPase-mediated cellular concentration and retention of quinacrine: a model for the distribution of lipophilic cationic drugs to autophagic vacuoles
Drug Metabolism and Disposition, 10/06/09
Marceau F et al. – Quinacrine is concentrated in cells via V–ATPase–mediated ion trapping with an apparent affinity ~500–fold higher than that of the less lipophilic drug procainamide and, despite the small size of ensuing vacuoles, the macroautophagic signature of this cytopathology was observed.
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