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See Latest ArticlesIs resistance useless? Multidrug resistance and collateral sensitivity
Trends in Pharmacological Sciences, 09/18/09
Hall MD et al. – When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the ATP–dependent efflux pump P–glycoprotein. P–gp can efflux a wide range of cancer drugs; its expression confers cross–resistance, termed “multidrug resistance”, to a wide range of drugs. Strategies to overcome this resistance have been actively sought for more than 30 years, yet clinical solutions do not exist. A less understood aspect of MDR is the hypersensitivity of resistant cancer cells to other drugs, a phenomenon known as “collateral sensitivity”.
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