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See Latest ArticlesReceptor trafficking induced by mu-opioid-receptor phosphorylation
Neuroscience & Biobehavioral Reviews, 09/16/09
Zhang Y et al. – One of the mechanisms for the development of tolerance and dependence is implicated to be opioid–receptor trafficking. Here the authors review the current understandings of opioid–receptor phosphorylation, endocytosis and desensitization after repeated agonist treatments. Also, the role of G–protein coupled receptor kinases in opioid–receptor phosphorylation is discussed. How to associate these observations to physiological and behavioral changes in animal models and clinics is still under investigation.
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Today in Basic Science...keeping you current
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