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Standardized Treatment of Active Tuberculosis in Patients with Previous Treatment and/or with Mono-resistance to Isoniazid: A Systematic Review and Meta-analysis
PLoS Medicine, 09/18/09

Menzies D et al. – There is little published evidence to support the continued use of the currently recommended retreatment regimen. There is an urgent need for a concerted international effort to substantially expand access to reliable drug sensitivity testing and to initiate randomized trials in patients with pretreatment drug resistance of all forms, particularly in previously treated patients. While awaiting results of these trials, the standardized retreatment regimen should be redesigned—at minimum to adequately treat patients with isoniazid resistance.

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