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Effect of Duration and Intermittency of Rifampin on Tuberculosis Treatment Outcomes: A Systematic Review and Meta-Analysis
PLoS Medicine, 09/18/09
Menzies D et al. – This review provides evidence against continued use of regimens that utilize rifampin for the first 2 mo only, as they are significantly and substantially inferior to regimens that use rifampin for at least 6 mo. This review also has identified an important need for adequately powered clinical trials that address dosing schedules, management of isoniazid mono–resistance, and the optimal duration of treatment to prevent relapse.
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