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Lee RVD et al. – A serious adverse event consisting of generalized muscle rigidity and laryngospasm can occur after bolus administration of morphine as well as during continuous infusion. Clinicians should be aware of this possibility.

Exclusive Author Commentary
Robin van der Lee, 10/23/09

In clinical practice many doctors recognize "bronchospasm" with the use of bolus administration of morphine, but somehow this never is described in the literature. This article uses the validated Naranjo Probability Algorithm to confirm generalized muscle rigidity is indeed a serious adverse effect of morphine.

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