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See Latest ArticlesInfluence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix opening, cytotoxic and anti-tumor activities
Molecular Pharmacology, 09/17/09
Depauw S et al. – The authors showed that the S– and R–orientations of the acetate on C1 asymmetric carbon lead to different local opening of the DNA, as visualized using nuclease S1 mapping. These different interactions could lead to modulated DNA–repair, protein/DNA interaction, and apoptosis processes.
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