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See Latest ArticlesSignaling pathways from CB1 receptor activation to inhibition of NMDA-mediated calcium influx and neurotoxicity in dorsal root ganglion neurons
Journal of Pharmacology and Experimental Therapeutics, 09/16/09
Liu Q et al. – The data suggest that WIN triggers a cascade of events: it activates the CB1 receptor and the IP3 signaling pathway, stimulates the release of Ca2+ from intracellular stores, raises the cytosolic Ca2+ levels, and inhibits the NMDA–mediated Ca2+ influx and cell death through a process that remains to be determined.
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