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Piroth L et al. – Cefotaxime and amoxicillin–clavulanate remained the most effective 'single' agents, however on less than 70% of isolates. Some combinations extended coverage to a further 15% of strains. Since inadequate empiric antibiotic therapy is associated with increased mortality, these combinations may be of great interest as first–line treatment, even though they may also lead to the development of antimicrobial resistance. Repeated epidemiological surveys and new clinical trials are thus needed.

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