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See Latest ArticlesEffects of Positive Allosteric Modulators on Single Cell Oscillatory Ca2+ Signaling Initiated by the Type 5 Metabotropic Glutamate Receptor
Molecular Pharmacology, 09/09/09
Bradley SJ et al. – The data demonstrate that allosteric modulators can "tune" the Ca2+ oscillation frequency initiated by mGlu5 receptor activation and this might allow pharmacological modification of the downstream processes unachievable through orthosteric ligand interactions.
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