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Reporting rate of adverse drug reactions to the French pharmacovigilance system with three step 2 analgesic drugs: dextropropoxyphene, tramadol and codeine
British Journal of Clinical Pharmacology, 09/08/09
Tavassoli N et al. – Among the three step 2 analgesic combinations, reporting rate and 'seriousness' of ADRs are the highest with TRM+P and the lowest with COD+P. The study suggests that the safety profile of DXP+P is worst than that of COD+P.
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