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Antivirals for Cytomegalovirus Infection in Neonates and Infants: Focus on Pharmacokinetics, Formulations, Dosing, and Adverse Events
Pediatric Drugs, 09/08/09
Marshall BC et al. – Neutropenia is the most frequent toxicity associated with ganciclovir and valganciclovir therapy, whereas significant renal toxicity can be seen with cidofovir. Foscarnet administration can also result in renal toxicity as well as significant electrolyte imbalances. Several of these drugs have potential toxicities that are of concern, including carcinogenesis, teratogenesis, and azospermia and deposition into bone or dentition that may have significant implications when treating an infant.
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