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See Latest ArticlesRole of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress
Archives of Pharmacal Research, 09/22/09
Surh YJ et al. – This review is intended to provide readers with a welldocumented account of the research done in the area of cellular adaptive survival response against nitrosative stress with special focus on the role of HO–1 upregulation, especially through activation of the transcription factor, Nrf2.
Young-Joon Surh, 09/27/09
| The redox-sensitive transcription factor represents a central component of cellular stress response mechanisms. One of the target proteins whose expression is upregulated by Nrf2 is heme oxygenase-1 (HO-1). The authors attempted to summarize the cutting-edge research on the role of Nrf2-mediated HO-1 induction in cellular defence against nitrosative stress which, like oxidative stress, is implicated in pathogenesis of a wide variety of human disorders. |
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