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See Latest ArticlesMultiple Switches in G Protein-Coupled Receptor Activation
Trends in Pharmacological Sciences, 09/18/09
Ahuja S et al. – The confluence of several required structural changes is an example of “coincidence counting”, which is often used by nature to regulate biological processes. In ligand–activated G protein–coupled receptors, the presence of multiple switches may provide an explanation for the differences between full, partial and inverse agonists.
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