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See Latest ArticlesThe Therapeutic Potential of the Endocannabinoid System for the Development of a Novel Class of Antidepressants
Trends in Pharmacological Sciences, 09/14/09
Hill MN et al. – Within preclinical models, facilitation of endocannabinoid neurotransmission evokes both antidepressant and anxiolytic effects. Similar to the actions of conventional antidepressants, enhancement of endocannabinoid signaling can enhance serotonergic and noradrenergic transmission; increase cellular plasticity and neurotrophin expression within the hippocampus; and dampen activity within the neuroendocrine stress axis.
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