Pharmacy Medical News about severe cancer pain; transdermal buprenorphine

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Managing severe cancer pain: the role of transdermal buprenorphine: a systematic review
Therapeutics and Clinical Risk Management, 09/09/09

Deandrea S et al. – The authors identified 19 eligible papers describing 12 clinical studies (6 randomized controlled trials and 6 observational prospective studies), including a total of about 5000 cancer patients. Given the poor quality of reports and the heterogeneity of methods and outcomes, pooling was not feasible as the type of data was not appropriate for combining the results statistically. A meta–analysis based on individual data is ongoing in the context of the Cochrane Collaboration. Although the narrative appraisal of each study suggests a positive risk benefit profile, well designed and statistically powered controlled clinical trials are needed to confirm this preliminary evidence.

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