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Cost-effectiveness of ACE inhibitor therapy to prevent dialysis in nondiabetic nephropathy: influence of the ACE insertion/deletion polymorphism
Pharmacogenetics and genomics, 09/14/09
Vegter S et al. – ACEi therapy is a cost–saving treatment compared with placebo in nondiabetic nephropathy, irrespective of ACE genotype. However, ACEi therapy saved more costs and more health gains were achieved in the ACE DD genotype than in the ACE II/ID genotype. An alternative treatment featuring a modest increase in effectiveness compared with ACEi therapy for patients with the ACE II/ID genotype can be incorporated in a cost–effective or even cost–saving screen–and–treat strategy.
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