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See Latest ArticlesShortcut Formulae for Pharmacokinetic Dosage Adjustments
Clinical Pharmacokinetics, 09/14/09
Belloto RJ – For intermittent infusions, the dosages calculated are equivalent to those obtained using the Sawchuk and Zaske method. With the shortcut formulae, it is more easily seen that most common dosage adjustments readily reduce to simple proportions or joint variation. These calculations can be quickly carried out with only the patient's terminal rate constant for linear pharmacokinetics and their Michaelis–Menten constant (Km) value for Michaelis–Menten kinetics.
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