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Management of loop diuretic resistance in the intensive care unit
American Journal of Health-System Pharmacy, 09/17/09

Asare K et al. – Loop diuretic resistance presents a challenge for clinicians in the ICU setting. Strategies to improve patients’ responsiveness to these agents include fluid and salt restriction, switching from oral to i.v. loop diuretics, increasing diuretic dose, continuous infusion, and combination therapy with thiazides. Several of these strategies may be used concurrently to combat diuretic resistance and promote symptomatic relief of edema in the critically ill patient.

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