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See Latest ArticlesTopiramate modulates excitability of the occipital cortex when measured by transcranial magnetic stimulation
Cephalalgia, 09/10/09
Aurora SK et al. – Topiramate modulates occipital cortex excitability in chronic migraine possibly via mechanisms of cortical inhibition. Since there was not a strong correlation between the degree of inhibition and reduction of migraine frequency, it would appear that topiramate did have an independent effect on cortical excitability that was not dependent on reduction in migraine frequency.
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