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Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation — a tale of three gases
Pharmacology & Therapeutics, 09/17/09
Li L et al. – It is becoming more clear that all three gases are synthesised naturally in the body, often by the same cells within the same organs, and that all three gases exert essentially similar biological effects albeit via different mechanisms. Within the cardiovascular system, for example, all are vasodilators, promote angiogenesis and vascular remodelling and are protective towards tissue damage in for example, ischaemia–reperfusion injury in the heart. Similarly, all exhibit complex effects in inflammation with both pro– and anti–inflammatory effects recognised.
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