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See Latest ArticlesKappa-opioid ligands in the study and treatment of mood disorders
Pharmacology & Therapeutics, 09/11/09
Carlezon WA et al. – Research from the group and others suggests that KOR antagonists might be useful for depression, KOR agonists might be useful for mania, and KOR partial agonists might be useful for mood stabilization. Currently available KOR agents have some unfavorable properties that might be addressed through medicinal chemistry. The development of KOR–selective agents with improved drug–like characteristics would facilitate preclinical and clinical studies designed to evaluate the possibility that KORs are a feasible target for new medications.
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