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See Latest Articlestert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: Inhibition of cytochrome P450 catalysis by steric hindrance
Molecular Pharmacology, 09/09/09
Hollenberg PF et al. – This large discrepancy in the stimulation of the first electron transfer by benzphetamine strongly suggests that the impairment of P450 catalysis is due to inhibition of benzphetamine binding to the tBPA–modified P450 2B4.
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