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Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells
BMC Pharmacology, 08/31/09
Vik–Mo AO et al. – This data show that stimulation of cellular lipid biosynthesis by amphiphilic psychotropic drugs is followed by a transcriptional activation of cholesterol transport and efflux pathways. Such effects may be relevant for both therapeutic effects and metabolic adverse effects of psychotropic drugs.
Today in Basic Science...keeping you current
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No evidence for functional selectivity of proxyfan at the human histamine H3-receptor coupled to defined Gi/Go protein heterotrimers
Journal of Pharmacology and Experimental Therapeutics, 12/04/09
Metabolic Fate of Lactoferricin Based Antimicrobial Peptides: Effect of Truncation and Incorporation of Amino Acid Analogs on the in vitro Metabolic Stability
Journal of Pharmacology and Experimental Therapeutics, 12/04/09
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis
Journal of Pharmacology and Experimental Therapeutics, 12/04/09
Today in Stomach/GI...keeping you current
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Resveratrol (trans-3, 5, 4'-trihydroxystilbene) induces SIRT1 and down-regulates NF-kB activation to abrogate DSS-induced colitis
Journal of Pharmacology and Experimental Therapeutics, 12/04/09
Oral ondansetron for reducing vomiting secondary to acute gastroenteritis in children – a double-blind randomized study
Alimentary Pharmacology and Therapeutics, 12/04/09
Atazanavir-Associated Choledocholithiasis Leading to Acute Hepatitis in an HIV-Infected Adult
Annals of Pharmacotherapy, 12/03/09
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