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See Latest ArticlesA Quantitative Enterohepatic Circulation Model: Development and Evaluation with Tesofensine and Meloxicam
Clinical Pharmacokinetics, 08/27/09
Lehr T et al. – A quantitative EHC model was successfully developed that was capable of describing the multiple peaks in plasma concentration–time profiles of tesofensine and meloxicam very well. Additionally, the model successfully quantified the observed results for an interruption of the meloxicam EHC. The model offers an in silico method to support an EHC hypothesis using standard pharmacokinetic data and might help to guide dosing recommendations of compounds undergoing EHC.
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