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See Latest ArticlesHypothesizing that histone deacetylase inhibitors can be used to reverse multiple drug resistance
Medical Hypotheses, 08/27/09
Jiang ZP et al. – It is hence hypothesized that epigenetic variants play more important roles than genetic polymorphism, thus adjusting the epigenetic factors could alter the expression of MDR, leading to the reverse of MDR. And it is further hypothesized that histone deacetylase inhibitors could be another strategy to overcome MDR. The mechanism may include a bidirectional modulation of P–gp by histone deacetylase inhibitors.
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