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Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children
Developmental Medicine & Child Neurology, 08/31/09
Rauchenzauner M et al. – Non–enzyme–inducing or minimal enzyme–inducing AED monotherapy does not cause vitamin D deficiency in otherwise healthy children with epilepsy. Valproate therapy is associated with increases in weight, body fat, and leptin concentration, as well as with a bone metabolic profile that resembles slightly increased parathyroid hormone action.
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