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Rituximab in combination with high-dose methylprednisolone for the treatment of chronic lymphocytic leukemia
Leukemia, 08/26/09

Castro JE et al. – High-dose methylprednisolone (HDMP) and rituximab is an effective non-myelosuppressive tx combination for patients with CLL

• 28 CLLL patients with a median age of 65 y
• HDMP at 1 g/m2 d x 3d in three 4w cycles with rituximab and prophylactic antimicrobial therapy

• Few adverse events of grade III+
• ORR 96%
• 32% CR
• Median PFS 30.3 mos with 39% requiring additional tx
• OS 96%

Today in Chemotherapy/Oncology...keeping you current

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Valproic acid restores ERalpha and antiestrogen sensitivity to ERalpha-negative breast cancer cells
Molecular and Cellular Endocrinology, 11/25/09

N2 Disease in Patients With Head and Neck Squamous Cell Cancer Treated With Chemoradiotherapy
Archives of Otolaryngology, 11/25/09

Salvage treatment with upfront melphalan 100 mg/m2 and consolidation with novel drugs for fulminant progression of multiple myeloma
Annals of Hematology, 11/24/09

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Drug-Drug Interaction Between Itraconazole and the Protease Inhibitor Lopinavir/Ritonavir
Annals of Pharmacotherapy, 11/25/09

Impact of pharmaceutical dosage form on stability and dissolution of roxithromycin
Central European Journal of Medicine, 11/24/09

Postoperative analgesia with minidose intrathecal morphine for bipolar hip prosthesis in extremely elderly patients
Journal of Anesthesia, 11/24/09

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Today in Drug Interactions...keeping you current

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Drug-Drug Interaction Between Itraconazole and the Protease Inhibitor Lopinavir/Ritonavir
Annals of Pharmacotherapy, 11/25/09

Daptomycin Versus Other Antimicrobial Agents for the Treatment of Skin and Soft Tissue Infections: A Meta-Analysis
Annals of Pharmacotherapy, 11/25/09

Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis
Pharmacogenetics and genomics, 11/23/09

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