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See Latest ArticlesThe Organic Cation Transporter, OCTN1, Expressed in the Human Heart, Potentiates Antagonism of the HERG Potassium Channel
Journal of Cardiovascular Pharmacology, 08/25/09
McBride BF et al. – Coexpression of the organic cation transporter, OCTN1, expressed in human cardiac myocytes, intensifies quinidine–induced HERG block. These findings establish a critical hypothesis that variable drug transporter activity may be a potential risk factor for torsade de pointes.
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