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Blood Pressure-lowering and Vascular Modulator Effects of Acorus calamus Extract Are Mediated Through Multiple Pathways
Journal of Cardiovascular Pharmacology, 08/25/09
Shah AJ et al. – These data indicate that crude extract possesses a combination of effects, relaxant effects mediated possibly through Ca+2 antagonism in addition to a nitric oxide pathway, although the associated vasoconstrictor effects may be meant by nature to offset excessive vasodilatation, thus providing a pharmacologic rationale to its cardiovascular medi–cinal uses.
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