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See Latest ArticlesPharmacokinetic-Pharmacodynamic and Response Sensitization Modeling of the Intraocular Pressure Lowering Effect of the EP4 Agonist, PF-04475270
Journal of Pharmacology and Experimental Therapeutics, 08/19/09
Luu KT et al. – This integrated PKPD model may have general utility when PD sensitization is observed and is not a result of time–dependent PK. In addition, the model is applicable in the ophthalmology drug development setting in which PK information is limited but a population–based PD model could reasonably be established.
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