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Meropenem Pharmacokinetics in the Newborn
Antimicrobial Agents and Chemotherapy, 08/27/09

Van Den Anker JN et al. – Given the distributions of estimated creatinine clearance and weight between pre–term and full–term neonates, meropenem clearance was substantially higher in the full–term group. A Monte Carlo simulation was performed using the creatinine clearance and weight distributions for pre–term and full–term populations separately, examining 20– and 40–mg/kg doses, 8– and 12–h dosing intervals, and 0.5–h and 4–h infusion times. The 8–h interval produced robust target attainments (both populations). If more resistant organisms were to be treated (MIC of 4 to 8 mg/liter), the 40–mg/kg dose and a prolonged infusion was favored. Treating clinicians need to balance dose choices for optimizing target attainment against potential toxicity. These findings require validation in clinical circumstances.

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