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See Latest ArticlesP38 mitogen-activated protein kinase (mapk) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 mapk dephosphorylation
Clinical and Experimental Pharmacology and Physiology, 08/20/09
Tsang MYC et al. – These data show that NA–induced p38 MAPK activation, through alpha–adrenoceptor, has a protective role in cardiomyocytes to antagonize NA–induced cell death. In contrast, beta–adrenoceptor stimulation produces dephosphorylation of p38 MAPK.
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