Your Messages Inbox
Most Viewed Abstracts
1. Report Shows Shift in Starting Salaries for Physicians 2. 2008 Exclusive Survey—Earnings: Good news for primary care income 3. Medicare pay-for-reporting effort draws fire from frustrated doctors 4. Debunking Myths in the US Healthcare System 5. Statins and cancer risk
Your Article Summary
See Latest ArticlesHigh occupancy of sigma 1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503
International Journal of Neuropsychopharmacology, 08/17/09
Ishikawa M et al. – The binding potential of [11C]SA4503 was calculated. Doses of 5 mg and 10 mg donepezil bound to sigma 1 receptors in the human brain with occupancies of –60% and –75%, respectively, in a dose–dependent manner. This study demonstrated that donepezil binds to sigma 1 receptors in the living human brain at therapeutic doses. Therefore, sigma 1 receptors may be implicated in the pharmacological mechanism of donepezil in the human brain.
Related Articles
Increase of SCF plasma concentration during donepezil treatment of patients with early Alzheimers disease
International Journal of Neuropsychopharmacology, 10/22/09
Relevance Score: 84%
Safety and Tolerability of Donepezil, Rivastigmine and Galantamine for Patients with Alzheimer's Disease: Systematic Review of the 'Real-World' Evidence
Dementia and Geriatric Cognitive Disorders, 11/10/09
Relevance Score: 83%
Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy
European Journal of Neurology, 11/03/09
Relevance Score: 83%
Cerebrolysin: A Review of its Use in Dementia
Drugs & Aging, 10/26/09
Relevance Score: 77%
Cholinesterase Inhibitors and Incidence of Bradycardia in Patients with Dementia in the Veterans Affairs New England Healthcare System
Journal of the American Geriatrics Society, 10/13/09
Relevance Score: 77%
Today in Dosing...keeping you current
Receive free subspecialty "5-minute updates" via email
Temporal Reduction of HIV Type 1 Viral Load in Breast Milk by Single-Dose Nevirapine during Prevention of MTCT
AIDS Research and Human Retroviruses, 12/18/09
Efficacy and safety of a single intrathecal methylprednisolone bolus in chronic complex regional pain syndrome
European Journal of Pain, 12/18/09
Low levels of steroid-metabolizing hepatic enzyme activity may elevate responsiveness to steroids and may increase risk of steroid-induced osteonecrosis even with low glucocorticoid dose
Journal of Orthopaedic Science, 12/18/09
Today in Neuro/Psych pharmacology...keeping you current
Receive free subspecialty "5-minute updates" via email
Modafinil for multiple sclerosis fatigue: Does it work
Clinical Neurology and Neurosurgery, 12/18/09
Treatment retention with risperidone long-acting injection: 24-month results from the Electronic Schizophrenia Treatment Adherence Registry in six countries
Current Medical Research and Opinion, 12/18/09
Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders
Phytotherapy Research, 12/18/09
Sponsor
Article Search
Sponsor
Sponsor