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See Latest ArticlesPentoxifylline prevents loss of pp2a phosphatase activity and recruitment of histone acetyltransferases to pro-inflammatory genes in acute pancreatitis
Journal of Pharmacology and Experimental Therapeutics, 08/12/09
Sandoval J et al. – The beneficial effects of pentoxifylline –and presumably of other phosphodiesterase inhibitors– in this disease seem to be mediated by abrogating the loss of cAMP levels and PP2A activity as well as chromatin modifying complexes very early during acute pancreatitis.
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