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See Latest ArticlesArmodafinil and Modafinil Have Substantially Different Pharmacokinetic Profiles Despite Having the Same Terminal Half-Lives: Analysis of Data from Three Randomized, Single-Dose, Pharmacokinetic Studies
Clinical Drug Investigation, 08/13/09
Darwish M et al. – Despite similar half–lives, plasma concentrations following armodafinil administration are higher late in the day than those following modafinil administration on a milligram–to–milligram basis. The different pharmacokinetic profile of armodafinil may result in improved wakefulness throughout the day in patients with ES compared with modafinil.
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