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Phase I Clinical Studies of the Advanced Glycation End-product (AGE)-Breaker TRC4186: Safety, Tolerability and Pharmacokinetics in Healthy Subjects
Clinical Drug Investigation, 08/13/09
Chandra KP et al. – TRC4186 was safe and well tolerated when administered orally with either a single or multiple doses across the different ages, sexes, races and formulations studied. A dose–proportional increase in plasma TRC4186 concentration was seen, with steady state being achieved within 6 days.
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