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See Latest ArticlesAssessing analgesic actions of opioids by experimental pain models in healthy volunteers - an updated review
British Journal of Clinical Pharmacology, 08/10/09
Staahl C et al. – The way the pain is induced, assessed and summarized is very important for the sensitivity of the pain models. This review gives an overview of how different opioids perform in experimental pain models. Generally experimental pain models need to be designed with careful consideration of pharmacological mechanisms and pharmacokinetics of analgesics. This knowledge can aid the decisions needed to be taken when designing experimental pain studies for compounds entering phase 1 clinical trials.
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