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See Latest ArticlesCognitive–Affective and Somatic Side Effects of Morphine and Pentazocine: Side-Effect Profiles in Healthy Adults
Pain Medicine, 08/10/09
Riley III JL et al. – The most frequently reported side effects across both drugs involved feeling relaxed, sedation, and feeling in control. At equianalgesic doses, pentazocine had greater aversive side effects than morphine, whereas morphine was more associated with feelings of control and euphoria. For both drugs, females reported greater frequency of negative side effects than males. Using cluster analysis, the authors identified similar symptom profiles for each drug. These drug–related side–effect profiles were linked with analgesic responses. Specifically, groups that had a more positive side–effect profile experienced the greatest analgesic effect based on changes in ischemic pain sensitivity. These findings have implications for decisions regarding opioid management of acute, chronic, and malignant pain conditions.
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