Pharmacy Medical News about Antidepressant

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. Statins and cancer risk

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

From Trial and Error to Trial Simulation. Part 1: The Importance of Model-Based Drug Development for Antidepressant Drugs
Clinical Pharmacology & Therapeutics, 08/07/09

Santen G et al. – Results show that data simulated using the DREM closely match individual patient data, including real–life dropout scenarios. In addition, parameterization in terms of interindividual variability ensures easier explanation of findings to clinical scientists, who ultimately make the relevant decisions.

Exclusive Author Commentary
O Della Pasqua, 08/08/09

This is the first of two articles on the relevance of clinical trial simulations in drug development and clinical research. The first article focuses on the requirements for statistical models which have clinical predictive value (i.e., describe patient response profiles), rather than just for the purpose of hypothesis testing. In the second paper, we show the advantages of clinical trial simulation over meta-analysis as the 'gold standard' method for assessing overall treatment effects or comparing differences between treatments. Statistical tools should not be left to statisticians alone. It is time physicians learn how to assess clinical relevance, rather than dwell solely on statistical significance.

<< Previous
Pharmacokinetics of tacrolimus co-administered with adefovir...

Next >>
H3 Receptor Antagonism Enhances NCAM PSA-Mediated Plasticity and...

Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effect
Bipolar Disorders, 11/24/09 Relevance Score: 89%

When starting an antidepressant, try either of these 2 drugs first
APCToday, 11/20/09 Relevance Score: 88%

Explaining Racial and Ethnic Differences in Antidepressant Use Among Adolescents
Medical Care Research and Review, 11/18/09 Relevance Score: 87%

The Role of Sodium Channels in the Mechanism of Action of Antidepressants and Mood Stabilizers
Current Drug Targets, 10/30/09 Relevance Score: 87%

Increase In Long-term Antidepressant Drug Use, UK Study Reveals
ScienceDaily, 10/26/09 Relevance Score: 87%