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Differential regulation of drug transporter expression by hepatocyte growth factor in primary human hepatocytes
Drug Metabolism and Disposition, 08/11/09
Vee ML et al. – These data demonstrate that HGF rather differentially regulates transporter expression in human hepatocytes, i.e. it repress most of the sinusoidal influx transporters whereas expression of most of the efflux transporters is unchanged or increased. Such changes may likely contribute to alterations of pharmacokinetics in patients suffering from diseases associated with increased plasma levels of HGF such as fulminant hepatitis.
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