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Knibbe CAJ et al. – Model–based simulations show that in newborns, including preterms, infants and children under the age of 3 years, a loading dose in micro g/kg and a maintenance dose expressed in micro g/kg1.5/h, with a 50% reduction of the maintenance dose in newborns younger than 10 days, results in a narrow range of morphine and metabolite serum concentrations throughout the studied age range.

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