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See Latest ArticlesPharmacokinetically Based Estimation of Patient Compliance with Oral Anticancer Chemotherapies
Clinical Pharmacokinetics, 08/17/09
Henin E et al. – The authors highlight the effect of three parameters on the quality of compliance estimates based on limited pharmacokinetic information: the plasma elimination half–life, interdose interval and magnitude of the error model. Nevertheless, the pharmacokinetic method is not informative enough and should be used with electronic monitoring, which provides additional information on compliance. This method will be used in a future phase IV clinical trial where the relationships between compliance, efficacy and tolerability will be assessed.
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