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The relationship between glucuronide conjugate levels and hepatotoxicity after oral administration of valproic acid
Archives of Pharmacal Research, 08/10/09
Lee MS et al. – The liver concentration of free 4–ene VPA and the urinary excretion of total 4–ene VPA were the only measures that correlated with the increase in the serum alpha–GST level. From these results, authors conclude that hepatotoxicity of VPA correlates with liver concentration of 4–ene VPA and can be predicted by the urinary excretion of total 4–ene VPA.
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